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VOLUME 92 | ISSUE 6 | PAGE 454
Stochastic bursts in the kinetics of gene expression with regulation by long non-coding RNAs
V. P. Zhdanov

Department of Applied Physics, Chalmers University of Technology, S-41296 Göteborg, Sweden
Boreskov Institute of Catalysis, Russian Academy of Sciences, 630090 Novosibirsk, Russia

Abstract
One of the main recent breakthroughs in cellular biology is a discovery of numerous non-coding RNAs (ncRNAs). We outline abilities of long ncRNAs and articulate that the corresponding kinetics may frequently exhibit stochastic bursts. For example, we scrutinize one of the generic cases when the gene transcription is regulated by competitive attachment of ncRNA and protein to a regulatory site. Our Monte Carlo simulations show that in this case one can observe huge long transcriptional bursts consisting of short bursts.


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