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VOLUME 84 | ISSUE 11 | PAGE 748
Stochastic bistable kinetics of gene transcription during the cell cycle
V. P. Zhdanov
Department of Applied Physics, Chalmers University of Technology, S-412 96 Göteborg, Sweden
Boreskov Institute of Catalysis RAS, 630090 Novosibirsk, Russia


PACS: 05.40.-a, 87.16.-b
Abstract
The positive feedback between messenger ribonucleic acid (mRNA) and regulatory-protein production may result in bistability of gene transcription. If in addition the mRNA and/or protein numbers in a cell are low, one can observe stochastic transcriptional ``bursts" provided that the intracellular conditions are steady. We present Monte Carlo simulations showing what may happen with the bursts under transient conditions during the cell cycle.


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